Current State of Research on the Mechanisms of Biological Activity of Alginates

Akoulina, E.A.; Bonartseva, G.A.; Dudun, A.A.; Kochevalina, M.Y.; Bonartsev, A.P.; Voinova, V.V.

Авторы: Akoulina Elizaveta A., Bonartseva Garina A., Dudun Andrey A., Kochevalina Marina Y., Bonartsev Anton P., Voinova Vera V.
Журнал: Biochemistry (Moscow)
Том: 90
Номер: S1
Год издания: 2025
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: S263
Последняя страница: S286
DOI: 10.1134/s0006297924604519
Аннотация: — Alginates are anionic unbranched plant and bacterial polysaccharides composed of mannuronicand guluronic acid residues. Alginates can form hydrogels under mild conditions in the presence of divalentcations (e.g., Ca2+). Because of their capacity to form gels, high biocompatibility, and relatively low cost, thesepolysaccharides are employed in pharmaceutical industry, medicine, food industry, cosmetology, and agriculture. Alginate oligomers produced by enzymatic cleavage of high-molecular-weight algal alginates are used asmedicinal agents and dietary supplements. The global market for alginate-based products exceeds $1 billion.Alginates and their oligomers have attracted a special interest in biomedical sciences due to manifestationof various types of therapeutic activity. Across more than 50-year history of studies of alginates, over 60%scientific articles in this field have been published in the last 5 years. Unfortunately, the works dedicated tothe mechanisms of biological activity of alginates and their oligosaccharides are still very scarce. This reviewanalyzes the current state of research on the mechanisms (mainly biochemical) underlying biological andtherapeutic activities of alginates (antioxidant, antibacterial, anti-inflammatory, antitumor, neuroprotective,antihypertensive, regenerative, and prebiotic). A comprehensive understanding of these mechanisms will notonly improve the efficiency of alginate application in medicine and other traditional fields (cosmetology, foodindustry), but might also reveal their potential in new areas such as tissue engineering, nanobiotechnology,and bioelectronics.
Добавил в систему: Кочевалина Марина Юрьевна

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