New Kinase Inhibitors That Are Selectively Cytotoxic for Tumor Cells

Авторы: Skvortsov D.A., Zhirkina I.V., Ipatova D.A., Pisarev A.R., Malyshev A.S., Ivanenkov Y.A., Kartsev V.G., Dontsova O.A.
Журнал: Doklady Biochemistry and Biophysics
Год издания: 2025
Издательство: M A I K Nauka - Interperiodica
Местоположение издательства: Russian Federation
DOI: 10.1134/s1607672924601446
Аннотация: To search for substances selectively acting on tumor cells, phenotypic screening in a coculture of tumor cells with non-tumor cells was used in the work. The compound STOCK7S-36520, selectively cytotoxic in the coculture of breast tumor cells MCF7' and non-tumor MCF10A cells, contains structural elements characteristic of kinase inhibitors. Analysis of the compound STOCK7S-36520 and its derivative STOCK7S-47016 showed that they are new multikinase inhibitors. The highest inhibition of 84% was shown by compound STOCK7S-47016 against GCK kinase. Of interest is the significant selectivity of action against some of the cell lines studied: the selectivity index of STOCK7S-36520 against the prostate tumor cell line PC3 is 29 times compared to the model line of non-tumor fibroblasts VA13.
Добавил в систему: Малышев Александр Сергеевич

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