Аннотация:—Susceptibility to audiogenic epilepsy (AE) seizures and phenotypic manifestations of epilepticactivity in rats of the Krushinsky–Molodkina (KM) strain were shown to develop in parallel with the appearance of seizure EEG patterns from 2 to 7 months of age. The seizure latency decreased with age, while theintensity of convulsive seizures increased. Two types of epileptiform discharges (EDs) were identified in background EEGs (no exposure to sound) of KM rats. One type had a form of high-amplitude generalized packsof waves with the animal shuddering. The other type had a form of generalized non-seizure absence-likespike-and-wave discharges with the animal freezing. The total and mean durations of single absence-like discharges increased with age. Parallel age-related increases in the severity of AE seizures and the number ofgeneralized absence-like discharges in the forebrain EEG suggests the development of the epileptic system inKM rats.
