Polymer-based mixed-mode stationary phases with grafted polyelectrolytes containing iminodiacetic acid functionalities

Uzhel, A.S.; Gorbovskaia, A.V.; Talipova, I.I.; Chernobrovkina, A.V.; Pirogov, A.V.

Авторы: Uzhel A.S., Gorbovskaia A.V., Talipova I.I., Chernobrovkina A.V., Pirogov A.V.
Журнал: Journal of Chromatography A
Год издания: 2025
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Номер статьи: 466062
DOI: 10.1016/j.chroma.2025.466062
Аннотация: A set of mixed-mode stationary phases based on two types of modified poly(styrene-divinylbenzene) (PS-DVB) with grafted polyelectrolytes containing iminodiacetic acid functionalities was synthesized and applied in hydrophilic interaction liquid (HILIC), reversed-phase high-performance liquid (RP-HPLC), and ion chromatography (IC). Preliminary modification of polymer substrate included Friedel-Crafts acylation or oxidation of residual double bonds on the particles surface. The prospect of using epoxidized substrate for grafting polyelectrolyte layer for obtaining selective and efficient resin for HILIC mode was demonstrated. On the contrary, the resin based on acylated substrate turned out advantageous for the separation of aromatic compounds in reversed-phase/ion-exchange mode. The obtained stationary phases were able to separate inorganic anions, oxyhalides, alkylphosphonates, water-soluble and fat-soluble vitamins, nucleosides and nucleobases, phenolic derivatives, and polycyclic aromatic hydrocarbons (PAHs). The introduction of iminodiacetic acid to the polyelectrolyte functional layer allowed achieving higher separation ability toward amino acids and phenols, as compared to previously obtained polyelectrolyte-grafted stationary phases. The separation of sucrose, maltose, and lactose was achieved for the first time on PS-DVB-based resins.
Добавил в систему: Ужель Анна Станиславовна

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Polymer-based mixed-mode stationary phases with grafted polyelectrolytes containing iminodiacetic acid functionalitiesстатья

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