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A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteinsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Sharapov Sodbo, Timoshchuk Anna, Zaytseva Olga, Maslov Denis E., Soplenkova Anna, Elgaeva Elizaveta E., Tiys Evgeny S., Mangino Massimo, Wittenbecher Clemens, Karssen Lennart, Timofeeva Maria, Nostaeva Arina, Vuckovic Frano, Trbojević-Akmačić Irena, Štambuk Tamara, Feoktistova Sofya, Potapova Nadezhda A., Voroshilova Viktoria, Williams Frances, Primorac Dragan, Van Zundert Jan, Georges Michel, Suhre Karsten, Allegri Massimo, Chaturvedi Nishi, Dunlop Malcolm, Schulze Matthias B., Spector Tim, Tsepilov Yakov A., Lauc Gordan, Aulchenko Yurii S.
- Журнал: Nature communications
- Том: 16
- Номер: 1
- Год издания: 2025
- Издательство: Nature Pub. Group
- Местоположение издательства: United Kingdom
- Номер статьи: 5525
- DOI: 10.1038/s41467-025-60431-y
- Аннотация: More than a half of plasma proteins are N-glycosylated. Most of them are synthesized, glycosylated, and secreted to the bloodstream by liver and lymphoid tissues. While associations with N-glycosylation are implicated in the rising number of liver, cardiometabolic, and immune diseases, little is known about the genetic regulation of this process. Here, we performed the largest genome-wide association study of N-glycosylation of the blood plasma proteome in 10,000 individuals. We doubled the number of genetic loci known to be associated with blood N-glycosylation by identifying 16 novel loci and prioritizing 13 novel genes contributing to N-glycosylation. Among these were the GCKR, TRIB1, HP, SERPINA1 and CFH genes. These genes are predominantly expressed in the liver and show a previously unknown genetic link between plasma protein N-glycosylation, metabolic and liver diseases, and inflammatory response. By integrating glycomics, proteomics, transcriptomics, and genomics, we provide a resource that facilitates deeper exploration of disease pathogenesis and supports the discovery of glycan-based biomarkers.
- Добавил в систему: Тимощук Анна Николаевна