Experimental Polymer Coating Provides Hemocompatibility to Glucose Sensors in Bloodstreamстатья
Информация о цитировании статьи получена из
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Дата последнего поиска статьи во внешних источниках: 17 октября 2017 г.
Аннотация:Background. The present in vitro study is a preclinical pilot experiment to develop materials that can be used for continuous direct blood glucose monitoring. Methods. Experimental polymer membrane coatings were created from the transesterified complex of nadroparin-γ-(aminopropyl)triethoxysilane and polyethylene glycol. The coatings were then fixed onto substrates with or without ultraviolet curing. Coating properties, such as thickness, defects, coating-to-membrane contact stability, general and glucose filtration rates, hemocompatibility, and hemolytic potential, were examined. Results. Ex vivo testing confirmed that the coatings were stable and did not slow the filtration rates of nitrofural, direct blue, and glucose. Coated membrane samples had no effect on the coagulation of unstabilized human blood ex vivo and did not reveal erythrocyte hemolysis in the samples during membrane incubation with blood over a period of 30 min to 24 h. Conclusion. The resultant coatings showed good hemocompatibility and did not affect the glucose filtration rate for selected membranes. It is possible that a sensor, which operates on glucose-selective coated membranes, placed in the bloodstream for a long time without degradation to create turbulence in the bloodstream or affect proximal blood coagulation or thrombogenesis requires validation by further preclinical studies in laboratory animals.