Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression

Pervouchine, D.D.; Djebali, S.; Breschi, A.; A, D.C.; Barja, P.P.; Dobin, A.; Tanzer, A.; Lagarde, J.; Zaleski, C.; See, L.; Fastuca, M.; Drenkow, J.; Wang, H.; Bussotti, G.; Pei, B.; Balasubramanian, S.; Monlong, J.; Harmanci, A.; Gerstein, M.; A, B.M.; Notredame, C.; Guigo, R.; R, G.T.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 апреля 2015 г.

Авторы: Pervouchine Dmitri D., Sarah Djebali, Alessandra Breschi, Davis Carrie A., Pablo Prieto Barja, Alex Dobin, Andrea Tanzer, Julien Lagarde, Chris Zaleski, Lei-Hoon See, Meagan Fastuca, Jorg Drenkow, Huaien Wang, Giovanni Bussotti, Baikang Pei, Suganthi Balasubramanian, Jean Monlong, Arif Harmanci, Mark Gerstein, Beer Michael A., Cedric Notredame, Roderic Guigo, Gingeras Thomas R.
Журнал: Nature communications
Том: 6
Номер: 5903
Год издания: 2015
Издательство: Nature Pub. Group
Местоположение издательства: United Kingdom
Первая страница: 1
Последняя страница: 11
DOI: 10.1038/ncomms6903
Аннотация: Mice have been a long-standing model for human biology and disease. Here we characterize, by RNA sequencing, the transcriptional profiles of a large and heterogeneous collection of mouse tissues, augmenting the mouse transcriptome with thousands of novel transcript candidates. Comparison with transcriptome profiles in human cell lines reveals substantial conservation of transcriptional programmes, and uncovers a distinct class of genes with levels of expression that have been constrained early in vertebrate evolution. This core set of genes captures a substantial fraction of the transcriptional output of mammalian cells, and participates in basic functional and structural housekeeping processes common to all cell types. Perturbation of these constrained genes is associated with significant phenotypes including embryonic lethality and cancer. Evolutionary constraint in gene expression levels is not reflected in the conservation of the genomic sequences, but is associated with conserved epigenetic marking, as well as with characteristic post-transcriptional regulatory programme, in which sub-cellular localization and alternative splicing play comparatively large roles.
Добавил в систему: Первушин Дмитрий Давидович

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Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expressionстатья

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