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A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continentsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 ноября 2017 г.
- Авторы: Carpenter C., Sidney J., Kolla R., Nayak K., Tomiyama H., Tomiyama C., Padilla OA, Rozot V., Ahamed SF, Ponte C., Rolla V., Antas PR, Chandele A., Kenneth J., Laxmi S., Makgotlho E., Vanini V., Ippolito G., Kazanova AS, Panteleev AV, Hanekom W., Mayanja-Kizza H., Lewinsohn D., Saito M., McElrath MJ, Boom WH, Goletti D., Gilman R., Lyadova IV, Scriba TJ, Kallas EG, Murali-Krishna K., Sette A., Lindestam Arlehamn CS
- Журнал: Tuberculosis
- Том: 95
- Год издания: 2015
- Издательство: Churchill Livingstone
- Местоположение издательства: United States
- Первая страница: 713
- Последняя страница: 721
- DOI: 10.1016/j.tube.2015.07.001
- Аннотация: We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.
- Добавил в систему: Лядова Ирина Владимировна