The factors affecting hydrolytic degradation kinetics of poly(D,L-lactide-co-glycolide) nanoparticles

Kulebyakina, A.I.; Streltsov, D.R.; Dmitryakov, P.V.; Kalinin, K.T.; Chvalun, S.N.

Авторы: Kulebyakina A.I., Streltsov D.R., Dmitryakov P.V., Kalinin K.T., Chvalun S.N.
Журнал: Colloids and Surfaces A: Physicochemical and Engineering Aspects
Том: 738
Год издания: 2026
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Номер статьи: 140010
DOI: 10.1016/j.colsurfa.2026.140010
Аннотация: The controlled degradation of poly(D,L-lactide-co-glycolide) nanoparticles is crucial for their biomedical applications as drug delivery systems. However, the effect of their size on hydrolysis kinetics under physiologically relevant conditions is not completely clear. In this study, the size effect was thoroughly investigated by dynamic light scattering, differential scanning calorimetry, and gel permeation chromatography. It was found that a decrease in the hydrodynamic diameter of the nanoparticles from 139 to 103 nm accelerates their hydrolytic degradation, the effective rate constant values at the initial degradation stage were estimated as 0.026 to 0.05 day− 1, correspondingly. It was revealed that the glass transition temperature of the nanoparticles in dry state as well as in an aqueous suspension is independent of their size in the studied size range, excluding the nanoconfinement effect on molecular mobility. Water diffusion into the polymer nanoparticles was shown to be fast compared to the hydrolysis rate ruling out the diffusion limited kinetics of the hydrolysis. Thus, the observedenhanced degradation rate with decreasing nanoparticle size was associated with increased specific surface area of the nanoparticles. The effects of temperature, pH, and γ-irradiation on the hydrolysis kinetics of PLGA nanoparticles have been also investigated.
Добавил в систему: Стрельцов Дмитрий Ростиславович

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