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Humic Substances as a Source of Novel Agents against TEM-1 betaLactamaseтезисы доклада
- Авторы: Alexandra Turkova, Alexander Zherebker, Maya Rubtsova, Vitaly Grigorenko, Irina Andreeva, Alexey Kononikhin, Oleg Kharybin, Eugene Nikolaev, Irina Perminova
- Сборник: Book of Abstracts. Fourth International Conference of CIS IHSS on Humic Innovative Technologies «From Molecular Analysis of Humic Substances – to Nature-like Technologies» (HIT-2017)
- Тезисы
- Год издания: 2017
- Место издания: ООО "КЛУБ ПЕЧАТИ" Москва
- Первая страница: 75
- Последняя страница: 75
- Аннотация: The microbial resistance to antibiotics is a global threat. Effectiveness of well-known single-molecule beta-lactamase inhibitors (BLIs) has diminished with the evolution of bacteria. Hence, new multi-target agents are in high demand. In this respect, humic substances (HS) deserve particular attention. HS are the products of abiotic combinatorial synthesis yielding supramolecular mixtures of natural organic compounds formed mostly by phenolic and carboxylic units. It was reported that they possess a broad spectrum of biological activity, such as anti-inflammatory and antiviral. Here we present a new BLIs and HS combination as an agent against TEM-1 beta-Lactamase.
- Добавил в систему: Жеребкер Александр Яковлевич