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Results of Simulation of Biological Activity of the Novel Polyphenolic Ligand of BP-C Family Drugs (in vitro and in silico)тезисы доклада
- Авторы: Elena Fedoros, Alexey Orlov, Alexander Zherebker, Ekaterina Izotova, Irina Perminova, Ekaterina Gubareva
- Сборник: Book of Abstracts. Fourth International Conference of CIS IHSS on Humic Innovative Technologies «From Molecular Analysis of Humic Substances – to Nature-like Technologies» (HIT-2017)
- Тезисы
- Год издания: 2017
- Место издания: ООО "КЛУБ ПЕЧАТИ" Москва
- Первая страница: 95
- Последняя страница: 95
- Аннотация: Natural substances, as safe and pluripotent candidates for designing medicinal products, draw interest of various scientific communities. By the present time methods for extraction and characterization of individual polyphenolic compositions and a solid evidence-based scientific database on potential molecular targets of these compositions have been developed. Biological activity of BP-Cx-1 was assessed by Dr. R. N. Karapetian et al. (ChemRar Institute), using in-vitro Cerep Diversity Profile (P9) screening panel. It was demonstrated that BP-Cx-1 interacts with 40 of the 97 tested targets. Biological activity of BP-Cx-1 was also simulated in-silico using the following input parameters: results of HPLC/HPLC-MS, obtained by the scientific group headed by Dr. E. I. Savelyeva (Scientific-Research Institute of Human Hygiene, Professional pathologies and Ecology of Federal MedicalBiological Agency of Russia, Saint-Petersburg), results of CHN, 13C NMR and FTICR-MS, latter ones generated by the group of Prof. I. V. Perminova (Moscow State University n.a. M.V. Lomonosov, Moscow) and results of 1H NMR, generated by Dr. K. A. Krasnov (Scientific Research Institute of Toxicology, Saint-Petersburg). CHN analyses demonstrated that BP-Cx-1 does not comprise any nitrogen-containing components; NMR spectra indicate that BP-Cx-1 comprises predominantly highly substituted polyphenols.
- Добавил в систему: Жеребкер Александр Яковлевич