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Lateral heterogeneity of the membrane liposomes in the present of plant polyphenols. Abstracts of 11th European biophysics congressтезисы доклада Тезисы
Информация о цитировании статьи получена из
Web of Science
Дата последнего поиска статьи во внешних источниках: 26 марта 2018 г.
- Авторы: Efimova S.S., Ostroumova O.S.
- Сборник: Eur. Biophys. J
- Серия: Suppl. 1
- Том: 46
- Тезисы
- Год издания: 2017
- Место издания: Edinburgh, Scotland
- Первая страница: S301
- Аннотация: We studied the effects of plant polyphenols (phloretin, phlorizin, quercetin, and myricetin) on the domain structure of liposomes mimicking the membranes of fungi, mammalian and plant cells. Using the fluorescence confocal microscopy of giant unilamellar vesicles composed of ternary mixtures of low-melting phospholipid (DOPC, POPC, or DPoPC), high-melting lipid (sphingomyelin, DPPC, or tetramyristoylcardiolipin) and sterol (cholesterol, or ergosterol) patterns of phase separation in liposomes in the absence and presence of polyphenols were investigated. We demonstrated that the phase segregation scenario is determined by the hydrophobic mismatch between ordered and disordered domains. Polyphenols depressed the phase segregation of membranes composed of SM, Chol, and POPC (or DOPC). Another ternary lipid mixtures tested were virtually insensitive to the introduction of modifiers. It was suggested that polyphenols affected the hydrophobic mismatch through the fluidization of the ordered and disordered domains. Ability of the modifier to immerse into membrane and to fluidize the domains depended on the hydrophobicity of the modifier molecules, geometric shape of domain-forming lipids, and their packing density.
- Добавил в систему: Ефимова Светлана Сергеевна