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Влияние цитокиновых иммуномодуляторов на динамику роста и метастазирование перевиваемой меланомы B16 в экспериментестатья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из перечня ВАК- Авторы: Златник Е.Ю., Новикова И.А., Золотарева Е.И., Шульгина О.Г., Непомнящая Е.М., Ульянова Е.П., Бондаренко Е.С.
- Журнал: Известия высших учебных заведений. Северо-Кавказский регион. Серия: Естественные науки
- Номер: 3-2
- Год издания: 2017
- Издательство: Федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет"
- Местоположение издательства: Ростов-на-Дону
- Первая страница: 37
- Последняя страница: 44
- Аннотация: The articles deals with the results of experimental studies of antitumor and antimetastatic effects of various combinations of immunomodulators Roncoleukin (IL-2), Ingaron (INF-γ) and Refnot (TNF-α with thymosin) and cytostatics (Doxorubicin). The study included C57Bl/6 mice; B16 melanoma was transplanted at a dose of 5×106 cells to animals of experimental groups. Immunomodulators were combined with each other or with cytostatics (Roncoleukin+Ingaron, Roncoleukin+Ingaron+Refnot, Roncoleukin+Doxorubicin, Roncoleukin+Refnot, Doxorubicin). Roncoleukin+Ingaron was the most effective combination: a high percentage of inhibition of tumor growth during the therapy (29.7 %) and after it (38.5 %), with antimetastatic effect (100 %). Inhibition of tumor growth was accompanied by morphologically registered dystrophic changes in tumor cells and a marked leukocyte infiltration. Morphological examination of the thymus showed a well-developed cortex with densely packed thymocytes supposing an active state of the T-cell immunity component which was confirmed by the results of a subpopulation analysis of spleen cells (increased levels of T-cells due to Th, compared to the controls). The results demonstrated antimetastatic and immunomodulating effects of Roncoleukin+Ingaron allowing considering this combination as the optimal one for cancer treatment. The study showed the importance of a search for effective combinations of immunomodulators.
- Добавил в систему: Золотарева Екатерина Игоревна