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Methodology for use of mitochondria-targeted cations in the field of oxidative stress-related researchстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 8 ноября 2016 г.
- Авторы: Vyssokikh MY, Antonenko YN, Lyamzaev KG, Rokitskaya TI, Skulachev VP
- Сборник: Methods Mol Biol
- Серия: Mitochondrial Medicine, Manipulating Mitochondrial Function
- Том: 1265
- Год издания: 2015
- Место издания: Springer New York Heidelberg Dordrecht London
- Первая страница: 149
- Последняя страница: 59
- DOI: 10.1007/978-1-4939-2288-8_12
- Аннотация: For many pathological conditions, reactive oxygen species (ROS) generated in mitochondria are considered to have a role as a trigger. When mitochondrial ROS (mROS) are formed in the inner mitochondrial membrane, they initiate free radical-mediated chain reactions of lipid peroxidation and are thus especially damaging. The consequences of membrane damage are decreased electrical resistance of the membrane, oxidative damage to cardiolipin (a mitochondria specifi c lipid essential for functioning of respiratory chain proteins and H + -ATP synthase), and damage to mitochondrial DNA localized in close vicinity to the inner membrane, with consequent mitochondrial dysfunction and induction of apoptotic cascade and cell death. To target the starting point of such undesirable events, antioxidants conjugated with mitochondria- targeted, membranepenetrating cations can be used to scavenge ROS inside mitochondria. The most demonstrative indications favoring this conclusion originate from recent discoveries of the in vivo effects of such cations belonging to the MitoQ and SkQ groups. Here we describe some essential methodological aspects of the application of mitochondria-targeted cations promising in treating oxidative stress-related pathologies.
- Добавил в систему: Лямзаев Константин Геннадьевич