A nanocomplex of C60 fullerene with cisplatin: design, characterization and toxicityстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 декабря 2017 г.
Аннотация:The self-organization of C60 fullerene and cisplatin (Cis) in aqueous solution was investigated using the computer simulation, dynamic light scattering and atomic force microscopy techniques. The results evidence the complexation between the two compounds. The genotoxicity of С60 fullerene, Cis and their complex was evaluated in vitro with comet assay using the human resting lymphocytes and lymphocytes after blast transformation. The cytotoxicity of mentioned compounds was estimated by Annexin V/PI double staining followed by flow cytometry. The results clearly demonstrate that water-soluble C60 fullerene nanoparticles (0.1 mg/ml) do not induce the DNA strand breaks in normal and transformed cells. C60 fullerene in the mixture with Cis does not influence genotoxic Cis activity in vitro and affects the cell death mode in treated resting human lymphocytes and reduces the fraction of necrotic cells.