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The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson ratsстатья
Информация о цитировании статьи получена из
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Дата последнего поиска статьи во внешних источниках: 6 мая 2019 г.
- Авторы: Miklyaeva Elena I., Woodward Nicole C., Nikiforov Edouard G., Tompkins Greg J., Klassen Frank, Ioffe Marat E., Whishaw Ian Q.
- Журнал: Behavioural Brain Research
- Том: 88
- Номер: 2
- Год издания: 1997
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 143
- Последняя страница: 152
- DOI: 10.1016/s0166-4328(97)00043-0
- Аннотация: Rats with unilateral dopamine (DA) depletions (hemiParkinson analogue rats) produced by intracerebral 6-hydroxydopamine injection are impaired in using the contralateral (bad) limbs for postural adjustments. This article examines whether the bad limbs are impaired in applying the forces required to initiate postural adjustments that anticipate and accompany voluntary movements. The rats were trained to reach for food using their good paw while standing on small platforms, each of which measured force changes produced by an individual limb. In one condition the force platforms were aligned to support the limb placement of normal rats and in the second they were aligned to permit the DA-depleted rats to use a compensatory reaching stance. It was found that the bad limbs of the DA-depleted rats produced normal supporting reactions but did not initiate adjustments in posture. Postural adjustments were initiated with the good limbs and preceded rather than accompanied the reaching movements. When constrained to use the posture of normal rats, the DA-deplete rats could not reach successfully, but when allowed to adjust their stance to increase reliance on the good limbs, reaching performance improved. Measures of ground reaction forces confirm that DA-depleted rats can support posture but cannot initiate postural adjustments with their impaired limbs.
- Добавил в систему: Устинова Ксения Ивановна