On the Mechanism and Functional Significance of the ADP/ATP Carrier (AAC) Dimerizationстатья
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Дата последнего поиска статьи во внешних источниках: 23 сентября 2020 г.
Аннотация:⎯According to previous studies, ADP/ATP carrier (AAC) can possibly exist as a monomer or in a
dimer state in the inner mitochondrial membrane; however, the question on its functional oligomeric state is
still open. The aim of the present work is to establish the external factors that could control the functional
oligomeric state of AAC (i.e., monomer or dimer). The study is based on the results of our previous work,
which revealed that the volume regulation system of mitochondria (MVRS) affects the oxidative phosphorylation
(OXPHOS) system: MVRS could transfer OXPHOS system functioning in a state of supercomplex.
Consequently, one may expect that the volume regulation system could also control the functional state of
AAC during phosphorylation. Here, on rat liver mitochondria we show that, depending on the incubation
medium tonicity, AAC functions in two different ways: either as a monomer (in hypotonic and isotonic
media) or as a dimer (in a hypertonic medium). Thus, the transition between the monomeric and dimeric
forms of AAC is regulated by MVRS, as well as by functioning of OXPHOS. We conclude that the structural
reorganization of AAC is associated with the entire OXPHOS reorganization into a supercomplex. It was also
found that dimerization of AAC can occur not only due to the action of MVRS (in hypotonic media) but also
under hypoxic conditions.