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Microbial origin of phenylcarboxylic acids in the human bodyстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 апреля 2016 г.
- Авторы: Beloborodova N.V., Khodakova A.S., Bairamov I.T., Olenin A.Y.
- Журнал: Biochemistry (Moscow)
- Том: 74
- Номер: 12
- Год издания: 2009
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 1657
- Последняя страница: 1663
- Аннотация: In previous studies we demonstrated increased amounts of phenylcarboxylic acids (PCA) in serum of patients with sepsis. This observation prompted the present study of the ability of the human microbiome bacteria to produce PCA in vitro. PCA were detected in culture media by gas chromatography–mass spectrometry. Increased amounts of phenyllac tic and phydroxyphenyllactic acids were produced by Klebsiella pneumonia, Escherichia coli, and Staphylococcus aureus. Certain strict anaerobes (bifidobacteria, lactobacteria, eubacteria) have also been found to actively produce these PCA, but these bacteria are not etiologically linked to sepsis. Thus our results demonstrate the ability of sepsisrelated bacteria to pro duce PCA and provide experimental support for the theory that the accumulation of PCA in the blood of patients with sep sis results from microbial degradation of phenylalanine and tyrosine.
- Добавил в систему: Осипов Артем Алексеевич
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