DNA specific fluorescent symmetric dimeric bisbenzimidazoles DBP(n): The synthesis, spectral properties, and biological activityстатья
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Дата последнего поиска статьи во внешних источниках: 15 июля 2015 г.
Аннотация:A series of new fluorescent symmetric dimeric bisbenzimidazoles DBP(n) bearing bisbenzimidazole
fragments joined by oligomethylene linkers with a central 1,4-piperazine residue were synthesized.
The complex formation of DBP(n) in the DNA minor groove was demonstrated. The DBP(n) at micromolar
concentrations inhibit in vitro eukaryotic DNA topoisomerase I and prokaryotic DNA methyltransferase
(MTase) M.SssI. The DBP(n) were soluble well in aqueous solutions and could penetrate cell and nuclear
membranes and stain DNA in live cells. The DBP(n) displayed a moderate effect on the reactivation of
gene expression.