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Extremophiles 2022 aims to present all the recent updates on basic and applied research on life in extreme environments, from both senior and early-career scientists. The program includes sessions on long-studied aspects such as origin of life, ecology, astrobiology, molecular biology, physiology, ecology and biotechnology. Additionally, we aim to highlight the multiple ways extremophiles can point us to sustainable solutions and help us expand our knowledge on the planetary boundaries during this era of accelerated climate change. In parallel, the organizers aspire for Extremophiles 2022 to provide a stimulus for inclusive research interactions, to inspire early career scientists and students through networking with senior and established scientists, and to pave the way for a bright future in this exciting fi eld.