Extraordinary genetic diversity in a wood decay mushroom

Baranova, M.A.; Logacheva, M.D.; Penin, A.A.; Seplyarskiy, V.B.; Safonova, Y.Y.; Naumenko, S.A.; Klepikova, A.V.; Gerasimov, E.S.; Bazykin, G.A.; James, T.Y.; Kondrashov, A.S.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 ноября 2015 г.

Авторы: Baranova Maria A., Logacheva Maria D., Penin Aleksey A., Seplyarskiy Vladimir B., Safonova Yana Y., Naumenko Sergey A., Klepikova Anna V., Gerasimov Evgeniy S., Bazykin Georgii A., James Timothy Y., Kondrashov Alexey S.
Журнал: Molecular Biology and Evolution
Том: 32
Номер: 10
Год издания: 2015
Издательство: Oxford University Press
Местоположение издательства: United Kingdom
Первая страница: 2775
Последняя страница: 2783
DOI: 10.1093/molbev/msv153
Аннотация: Populations of different species vary in the amounts of genetic diversity they possess. Nucleotide diversity π, the fraction of nucleotides that are different between two randomly chosen genotypes, has been known to range in eukaryotes between 0.0001 in Lynx lynx and 0.16 in Caenorhabditis brenneri. Here, we report the results of a comparative analysis of 24 haploid genotypes (12 from the USA, and 12 from European Russia) of a split-gill fungus Schizophyllum commune. The diversity at synonymous sites is 0.20 in the American population of S. commune, and 0.13 in the Russian population. This exceptionally high level of nucleotide diversity also leads to extreme amino acid diversity of protein-coding genes. Using whole-genome resequencing of two parental and seventeen offspring haploid genotypes, we estimate that the mutation rate in S. commune is high, at 2.0×10-8 (95% CI 1.1×10-8 to 4.1×10-8) per nucleotide per generation. Therefore, the high diversity of S. commune is primarily determined by its elevated mutation rate, although high effective population size likely also plays a role. Small genome size, ease of cultivation and completion of the life cycle in the laboratory, free-living haploid life stages and exceptionally high variability of S. commune make it a promising model organism for population, quantitative, and evolutionary genetics.
Добавил в систему: Пенин Алексей Александрович

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Extraordinary genetic diversity in a wood decay mushroomстатья

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