NEW ALLOSTERIC AMPA RECEPTOR MODULATORS BASED ON TRICYCLIC BISPIDINE DERIVATIVES WITH INDANE MOIETY

Авторы: Golubeva E.A., Lavrov M.I., Zamoyski V.L., Grigoriev V.V., Palyulin V.A.
Сборник: XIII International Conference on Chemistry for Young Scientists “MENDELEEV 2024”. St Petersburg. September 2–6, 2024. Book of abstracts
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Год издания: 2024
Место издания: VVM Publishing LLC St Petersburg
Первая страница: 432
Аннотация: One of the key areas of modern medicinal chemistry is devoted to the development of new drugs for the treatment of psychoneurological and neurodegenerative diseases. A very important biological target of such drugs is the glutamatergic system. Among the substances acting on the glutamatergic system, the most interesting are allosteric modulators of the AMPA receptor.In this work, a series of new tricyclic bispidine derivatives with indane moiety was obtained through a 9-step divergent synthesis. The resulting compounds have demonstrated high modulatory activity towards the AMPA receptor in in vitro studies using the electrophysiological patch clamp method.
Добавил в систему: Голубева Елена Андреевна

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